The Provision and Maintenance of Two Mass Spectrometry systems

Description

The MHRA has a requirement to award a contract for The Provision and Maintenance of Two Mass Spectrometry systems to one Tenderer as replacements of two Triple Quad Mass Spectrometers (s/n TQH-Q1-0526 and TQH-Q1-0525) for quantification and characterisation of biological medicine standards, including influenza, and to support counterfeit and sub-potent medicine characterisation. These systems are to be purchased with service maintenance and any bespoke consumables required to run the systems as follows: System 1. A high-resolution mass spectrometer coupled with a low flow liquid chromatography (LC) system (hereinafter referred to as a “high resolution mass spectrometry system” or “HRMS system”). The system should include all the instrumentation and software to allow qualitative and quantitative analysis of samples in a wide range of complex biological matrices in the areas of proteomics, intact protein analysis, biopharmaceutical characterisation, e.g. multi-attribute monitoring of therapeutic antibodies, post-translational modifications and small molecules/metabolomics as well as glycoproteins and oligonucleotides (OGNs). System 2. A triple quadrupole mass spectrometer coupled with an ultra-high performance liquid chromatography (UPLC) (hereinafter referred to as a “triple quad MS system”). The system should include all the instrumentation and software to allow for high throughput targeted quantitative analysis across biopharma, clinical and small molecule applications, supporting large SRM/MRM panels.

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