UK Public Sector Contracts & Tenders

Genomics England's Newborns Genome Programme is co-designing and running an NHS-embedded research study to explore the benefits, challenges, and practicalities of sequencing and analysing the genomes of newborns through using whole genome sequencing (WGS). The evidence gathered from the study will be evaluated rigorously to inform decisions about whether to roll-out this technology and develop the world's first national newborn screening programme that uses whole genome sequencing. One of the Programme's objectives is to understand how newborns' genomic and health data could be used for discovery research - for example, to enable the development of new diagnostics and treatments. With parents' consent, babies' genomes could be de-identified and added, alongside their health data, to Genomics England's National Genomic Research Library. This would enable carefully vetted academic, clinical, and life science industry researchers to develop novel diagnostics and treatments as well as understand how current therapies can be improved or repurposed, offering better outcomes to NHS patients. We are aware of particular sensitivities in society generally around the long-term storage and use of genomic and related health data in the context of research. To address these concerns, to date we have carried out small-scale in-house research with mothers or expectant mothers, where we have explored their feelings around how researchers could access and use newborns' genomes for research. However, this procurement aims to broaden these discussions, and unpack people's views on various options and approaches for the Programme's discovery research strategy. This procurement will support these aims, enabling in-depth exploration of attitudes and views on different types of data that could be drawn on for the Programme's research strategy, the acceptable and appropriate scope of research on these data, and specific mechanisms for creating a trustworthy system for doing so.

Genomics England's Newborns Genome Programme is co-designing and running an NHS-embedded research study to explore the benefits, challenges, and practicalities of sequencing and analysing the genomes of newborns through using whole genome sequencing (WGS). The evidence gathered from the study will be evaluated rigorously to inform decisions about whether to roll-out this technology and develop the world's first national newborn screening programme that uses whole genome sequencing. One of the Programme's objectives is to understand how newborns' genomic and health data could be used for discovery research - for example, to enable the development of new diagnostics and treatments. With parents' consent, babies' genomes could be de-identified and added, alongside their health data, to Genomics England's National Genomic Research Library. This would enable carefully vetted academic, clinical, and life science industry researchers to develop novel diagnostics and treatments as well as understand how current therapies can be improved or repurposed, offering better outcomes to NHS patients. We are aware of particular sensitivities in society generally around the long-term storage and use of genomic and related health data in the context of research. To address these concerns, to date we have carried out small-scale in-house research with mothers or expectant mothers, where we have explored their feelings around how researchers could access and use newborns' genomes for research. However, this procurement aims to broaden these discussions, and unpack people's views on various options and approaches for the Programme's discovery research strategy. This procurement will support these aims, enabling in-depth exploration of attitudes and views on different types of data that could be drawn on for the Programme's research strategy, the acceptable and appropriate scope of research on these data, and specific mechanisms for creating a trustworthy system for doing so. To find out more about this opportunity and access the tender documents please register at https://genomicsengland.bravosolution.co.uk/genomicsengland/web/login.html and search for project_821

In this piece of work we are looking for a supplier to engage with ethnic minority community leaders to establish how Genomics England should work with members of those communities while designing and delivering our consent process. Additional information: In order to bid for this opportunity, you must register at our e-tendering portal (Bravo) using the link below. There, you will find all the relevant documentation by searching for "Consent Dialogue - Newborns" under project code "project_825". If you have any questions, you may contact us via email on supplier.engagement@genomicsengland.co.uk

In this piece of work we are looking for a supplier to engage with ethnic minority community leaders to establish how Genomics England should work with members of those communities while designing and delivering our consent process. Additional information: In order to bid for this opportunity, you must register at our e-tendering portal (Bravo) using the link below. There, you will find all the relevant documentation by searching for "Consent Dialogue - Newborns" under project code "project_825". If you have any questions, you may contact us via email on supplier.engagement@genomicsengland.co.uk

To support the development of the Newborns Programme, we are seeking an agency to provide newborn photography that represents the parents we want to reach. We want to capture images of first-time parents feeling at ease that they've had the opportunity to find out early if their baby might need extra medical care as they grow up. If you are interested in bidding for this opportunity, please register at https://genomicsengland.bravosolution.co.uk/ and search for project_841

To support the development of the Newborns Programme, we are seeking an agency to provide newborn photography that represents the parents we want to reach. We want to capture images of first-time parents feeling at ease that they've had the opportunity to find out early if their baby might need extra medical care as they grow up.

Genomics England (GEL) are seeking an Intranet Solution that prioritises user experience and is not limited to team-specific requirements. If you are interested in bidding for this tender, please register via our e-procurement portal at https://public.bravosolution.co.uk/genomicsengland/web/login.html and search for reference "project_852" - Intranet Solution. There you will find the tender documents and more information.

Genomics England's current CEO Chris Wigley has been with the business for nearly 4 years and has done an outstanding job. Baroness Nicola Blackwood, Chair of the Board at Genomics England, announced on 16th May 2023 that CEO Chris Wigley will be moving on from the role in late 2023. We are starting a recruitment process to appoint a recruitment firm to help us secure the next CEO. Interested parties should register for the opportunity by logging into https://genomicsengland.bravosolution.co.uk/genomicsengland/web/login.html and searching for project_853.

Genomics England’s Generation Study aims to explore the benefits, challenges, and practicalities of offering whole genome sequencing to newborns, to accelerate diagnosis and access to treatment for rare genetic conditions. The programme funding was confirmed on 13 December 2022 with £105 million of funding to support it. Should it prove beneficial for participants and the wider health service, the study could pave the way for what would be the world’s first national newborn screening programme to incorporate whole genome sequencing. The outcome for this project is for Genomics England to work in partnership with an organisation or group of organisations with the specific expertise to deliver the Generation Study evaluation. The Generation Study will: 1. evaluate the scientific and clinical utility and validity, operational feasibility, and impact on the NHS of using Whole Genome Sequencing to screen for a large number of childhood-onset rare genetic conditions and provide ongoing patient support 2. understand how, with consent, newborns’ genomic and health data could be used for research to enable new diagnostic discoveries and treatments to be developed 3. explore the potential risks, benefits, and broader implications of storing an individual’s genome over their lifetime (e.g., potential for preventative steps, personalised risk-based screening in later life etc.) Please note that this tender seeks a partner to evaluate the first of these three aims only.

This procurement focuses on the facilitation and management of a group of members of the public drawn from previous dialogues to deliberate on: The implications of storing a baby's genome over their lifetime Other issues, as they arise, in the delivery of the Generation Study - particularly those which would benefit from public deliberation The group will need to run for a period of one year and examples of the issues that might be deliberated on include: - Expectations of genomics over a babies' lifetime: exploring acceptable uses - Involving young people as they grow up: navigating consent and assent - Disclosing genomic findings over a person's lifetime: how, when, why, who? - Relationships between genomic and wider health data - Health records and the incorporation of genomic data - Clinical access to genomic data: exploring the boundaries - Genomic futures: newborn screening implications for the future of prenatal testing - Reanalysing genomic data: exploring parameters Additional information: Please register on the e-tendering portal (Bravo) on the link provided. Once registered, you can find the opportunity under project title Public Standing Group on Ethics or the project reference "project_868".

Genomics England are looking for a provider to support in digitising all the histopathology slides from the participants of the 100,000 Genomes Project so they can be transferred to the multi-modal research environment. The multi-modal project provides an enriched data set for cancer research by adding of imaging data from pathology slides and radiology images (e.g., x-ray, CT and MRI) alongside whole genome data. The multi-modal project aims are: - Complete the scanning and digitisation of the remaining 200,000 histopathology slides for the 100,000 Genomes Project participants. - Make accessible to researchers a secure library of linked genomic, clinical and imaging cancer data accompanied with the tooling needed to accelerate the understanding of the morphological, genomic and clinical changes that occur in cancer. - Lead the research community to generate new insights from the data to support diagnostic, prognostic and precision medicine discovery. How to apply If you have not already done so, you will need to register on our Bravo portal https://public.bravosolution.co.uk/genomicsengland/web/login.html Please register on the e-tendering portal (Bravo) on the link provided. Once registered, you can find the opportunity under project title Services for slide digitisation - multi-modal or the project reference "project_867" All correspondence should be sent via the portal. To note, the project will go live and can be accessed from w/c 4th December 2023.

Genomics England are looking for a provider to support in digitising all the histopathology slides from the participants of the 100,000 Genomes Project so they can be transferred to the multi-modal research environment. The multi-modal project provides an enriched data set for cancer research by adding of imaging data from pathology slides and radiology images (e.g., x-ray, CT and MRI) alongside whole genome data. The multi-modal project aims are: - Complete the scanning and digitisation of the remaining 200,000 histopathology slides for the 100,000 Genomes Project participants. - Make accessible to researchers a secure library of linked genomic, clinical and imaging cancer data accompanied with the tooling needed to accelerate the understanding of the morphological, genomic and clinical changes that occur in cancer. - Lead the research community to generate new insights from the data to support diagnostic, prognostic and precision medicine discovery. How to apply If you have not already done so, you will need to register on our Bravo portal https://public.bravosolution.co.uk/genomicsengland/web/login.html Please register on the e-tendering portal (Bravo) on the link provided. Once registered, you can find the opportunity under project title Services for slide digitisation - multi-modal or the project reference "project_867" All correspondence should be sent via the portal.

Genomics England are looking for a provider to support in digitising all the histopathology slides from the participants of the 100,000 Genomes Project so they can be transferred to the multi-modal research environment. The multi-modal project provides an enriched data set for cancer research by adding of imaging data from pathology slides and radiology images (e.g., x-ray, CT and MRI) alongside whole genome data. The multi-modal project aims are: - Complete the scanning and digitisation of the remaining 200,000 histopathology slides for the 100,000 Genomes Project participants. - Make accessible to researchers a secure library of linked genomic, clinical and imaging cancer data accompanied with the tooling needed to accelerate the understanding of the morphological, genomic and clinical changes that occur in cancer. - Lead the research community to generate new insights from the data to support diagnostic, prognostic and precision medicine discovery. How to apply The opportunity will go live on Monday 4th December. If you have not already done so, you will need to register on our Bravo portal https://public.bravosolution.co.uk/genomicsengland/web/login.html and inform us of the email address or supplier ID associated with your account. You will be invited to the opportunity and able to access the documents - all correspondence should be sent via the portal once the opportunity goes live.

Genomics England are looking for a provider to support in digitising all the histopathology slides from the participants of the 100,000 Genomes Project so they can be transferred to the multi-modal research environment. The multi-modal project provides an enriched data set for cancer research by adding of imaging data from pathology slides and radiology images (e.g., x-ray, CT and MRI) alongside whole genome data. The multi-modal project aims are: - Complete the scanning and digitisation of the remaining 200,000 histopathology slides for the 100,000 Genomes Project participants. - Make accessible to researchers a secure library of linked genomic, clinical and imaging cancer data accompanied with the tooling needed to accelerate the understanding of the morphological, genomic and clinical changes that occur in cancer. - Lead the research community to generate new insights from the data to support diagnostic, prognostic and precision medicine discovery.

Genomics England are looking for a provider to support in digitising all the histopathology slides from the participants of the 100,000 Genomes Project so they can be transferred to the multi-modal research environment. The multi-modal project provides an enriched data set for cancer research by adding of imaging data from pathology slides and radiology images (e.g., x-ray, CT and MRI) alongside whole genome data. The multi-modal project aims are: - Complete the scanning and digitisation of the remaining 200,000 histopathology slides for the 100,000 Genomes Project participants. - Make accessible to researchers a secure library of linked genomic, clinical and imaging cancer data accompanied with the tooling needed to accelerate the understanding of the morphological, genomic and clinical changes that occur in cancer. - Lead the research community to generate new insights from the data to support diagnostic, prognostic and precision medicine discovery.

Genomics England are looking for a provider to support in digitising all the histopathology slides from the participants of the 100,000 Genomes Project so they can be transferred to the multi-modal research environment. The multi-modal project provides an enriched data set for cancer research by adding of imaging data from pathology slides and radiology images (e.g., x-ray, CT and MRI) alongside whole genome data. The multi-modal project aims are: - Complete the scanning and digitisation of the remaining 200,000 histopathology slides for the 100,000 Genomes Project participants. - Make accessible to researchers a secure library of linked genomic, clinical and imaging cancer data accompanied with the tooling needed to accelerate the understanding of the morphological, genomic and clinical changes that occur in cancer. - Lead the research community to generate new insights from the data to support diagnostic, prognostic and precision medicine discovery. How to apply If you have not already done so, you will need to register on our Bravo portal https://public.bravosolution.co.uk/genomicsengland/web/login.html Please register on the e-tendering portal (Bravo) on the link provided. Once registered, you can find the opportunity under project title Services for slide digitisation - multi-modal or the project reference "project_867" All correspondence should be sent via the portal. To note, the project will go live and can be accessed from w/c 4th December 2023.

Genomics England is seeking a supplier to provide accelerated combined extraction and sequencing services in support of the Generation Study programme.

Genomics England seeks to implement a query layer to sit on top of a single location as tool that allows users or other apps to query the data. This means that the actual data can remain in place while the query layer handles providing the correct access and views of the data. The query layer will allow for simplified access control that can be rolled out downstream, scaling up and down on demand by controlling number of nodes and make it significantly easier to manage changes either to front end applications or upstream with ETL pipeline. The contract will be for provision of an API, implementation of the solution plus 5 years of licencing and support. Additional information: To apply, you will need to register on our Bravo portal https://public.bravosolution.co.uk/genomicsengland/web/login.html Once registered, you can find the opportunity under project title Data Query Layer Software or the project reference "project_872" All correspondence should be sent via the portal.

Genomics England seeks to implement a query layer to sit on top of a single location as tool that allows users or other apps to query the data. This means that the actual data can remain in place while the query layer handles providing the correct access and views of the data. The query layer will allow for simplified access control that can be rolled out downstream, scaling up and down on demand by controlling number of nodes and make it significantly easier to manage changes either to front end applications or upstream with ETL pipeline. The contract will be for provision of an API, implementation of the solution plus 5 years of licencing and support.